欧洲杯下注

语言选择:简体 / 繁體 / English

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSIZHAOBIAOGONGGAO

心血管疾病

辛伐他汀片

【GUI   GE】10mg,20mg

【BAO   ZHUANG】KOUFUGUTIYAOYONGGAOMIDUJUYIXIPING(1)10mg:10PIAN/PING,20PIAN/PING ;1PING/HE;(2)20mg:10PIAN/PING;1PING/HE;

【DAN   WEI】PIAN

【PIZHUNWENHAO】10mg:GUOYAOZHUNZIH20065119  20mg:GUOYAOZHUNZIH20065120。



分享:
  • 药品介绍
  • 适应症
  • 用法用量

OUZHOUBEIXIAZHU:【YAOPINMINGCHENG】

OUZHOUBEIXIAZHU:TONGYONGMINGCHENG:XINFATATINGPIAN 

OUZHOUBEIXIAZHU:YINGWENMINGCHENG:Simvastatin Tablets 

OUZHOUBEIXIAZHU:HANYUPINYIN:Xinfatating Pian

OUZHOUBEIXIAZHU: 

【CHENG    FEN】BENPINZHUYAOCHENGFENWEIXINFATATING。HUAXUEMINGCHENG: 2,2-ERJIAJIDINGSUAN(4R,6R)-6-[2-[(1S,2S,6R,8S,8αR)-1,2,6,7,8,8α-LIUQING-8-QIANGJI-2,6-ERJIAJI-1-NAIJI] YIJI] SIQING-4-QIANGJI-2H-BINAN-2-TONG-8-ZHI。

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU:HUAXUEJIEGOUSHI:

 3.jpg

欧洲杯下注:分子式:C25H38O5

OUZHOUBEIXIAZHU:FENZILIANG:418.57

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU:【XING    ZHUANG】BENPINWEIBOMOYIPIAN,CHUQUBAOYIHOUXIANBAISEZHIDANHUANGSE。

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU:【BULIANGFANYING】

BENPINYIBANNAISHOUXINGLIANGHAO,DABUFENBULIANGFANYINGQINGWEIQIEWEIYIGUOXING。ZAIDUIZHAOLINCHUANGYANJIUZHONGBUZU2%DEHUANZHEYINBENPINDEBULIANGFANYINGERZHONGTUTINGYAO。ZAISHANGSHIQIANDEDUIZHAOLINCHUANGYANJIUZHONG,YANJIUZHERENWEIYUYAOWUYOUGUAN(FENWEIKENENG、HENKENENGHUOKENDING)QIEFASHENGLV≥1%DEBULIANGFANYINGYOUFUTONG、BIANMIHEWEICHANGZHANGQI;FASHENGLVWEI0.5~0.9%DEBULIANGFANYINGYOUPIFAWULIHETOUTONG。JIBINGDEBAODAOHENHANJIAN。JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE。

OUZHOUBEIXIAZHU: 

ZAIHPSYANJIUZHONG,GONGYOU20536MINGHUANZHEMEIRIFUYONGBENPIN40mg(n=10269)HUOANWEIJI(n=10267),PINGJUNGUANCHASHIJIANWEI5NIAN,LIANGZUJIANDEANQUANXINGXIANGSI。ZHEIXIANGDAXINGSHIYANZHIJILULEYANZHONGBULIANGFANYINGHEYINFUZUOYONGERTUICHUYANJIUDERENSHU。LIANGZUJIANYINBULIANGFANYINGTUICHUDEBILISHIXIANGSIDE(XINFATATINGZU4.8%,ANWEIJI5.1%)。XINFATATINGZUZHONGDEJIBINGFASHENGLVXIAOYU0.1%。XINFATATINGZUHEANWEIJIZUDEZHUANANMEISHENGGAO(ZHONGFUJIANCHAZHONG,CHAOGUOZHENGCHANGZHISHANGXIAN3BEIYISHANG)DEBILIFENBIEWEI0.21%(n=21)HE0.09%(n=9)。ZAIBEIOUXINFATATINGSHENGCUNYANJIU(4S)ZHONG,4444MINGHUANZHEMEITIANFUYONGBENPIN20~40mg(n=2221)HUOANWEIJI(n=2223),SUIFANGSHIJIANDEZHONGWEISHUWEI5.4NIAN,LIANGZUJIANDEANQUANXINGJINAISHOUXINGXIANGSI。ZAIWUDUIZHAOLINCHUANGYANJIUHUOSHANGSHIHOUDEYINGYONGZHONGBAODAOGUOXIALIEBULIANGFANYING:EXIN、FUXIE、PIZHEN、XIAOHUABULIANG、SAOYANG、TUOFA、YUNXUAN、JIROUJINGLUAN、JITONG、YIXIANYAN、GANJUEYICHANG、WAIZHOUSHENJINGBINGBIAN、SHIMIAN、YIYU、OUTU,PINXUE,BOQIGONGNENGZHANGAIHEJIANZHIXINGFEIBING。JISHAOFASHENGHENGWENJIRONGJIEHEGANYAN/HUANGDAN,JIHANJIANYOUZHIMINGJIFEIZHIMINGGANSHUAIJIEDEFASHENG。HANJIANYOUYUSHIYONGTATINGYOUGUANDEMIANYIJIEDAOXINGHUAISIXINGJIBING(IMNM)(YIZHONGZISHENMIANYIXINGJIBING)DEBAOGAO。

OUZHOUBEIXIAZHU: 

IMNMDETEZHENGWEI:JINDUANJIWULIHEXUEQINGJISUANJIMEISHENGGAO(TINGYONGTATINGHOUZHENGZHUANGRENGRANCUNZAI);JIROUHUOJIANXIANSHIWEIWUXIANZHUYANZHENGDEHUAISIXINGJIBING;YINGYONGMIANYIYIZHIJIHOUGAISHAN(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。

BAOKUOXIALIEYIXIANGHUODUOXIANGZHENGZHUANGDEMINGXIANDEGUOMINFANYINGZONGHEZHENGHANYOUBAODAO:GUOMINXINGFANYING,XUEGUANSHENJINGXINGSHUIZHONG、LANGCHUANGYANGZONGHEZHENG、FENGSHIXINGDUOFAXINGJITONG、PIFUJIYAN、MAIGUANYAN、XUEXIAOBANJIANSHAOZHENG、SHISUANXINGXIBAOZENGDUO、HONGXIBAOCHENJIANGLV(ESR)SHENGGAO、GUANJIEYAN、GUANJIETONG、QIANMAZHEN、GUANGMINGAN、FASHAO、CHAOHONG、HUXIKUNNANYIJIBUSHI。

SHANGSHIHOUJINGYAN:TATINGLEIYAOPINDEGUOWAISHANGSHIHOUJIANCEZHONGYOUHANJIANDERENZHIZHANGAIDEBAODAO,BIAOXIANWEIJIYILISANGSHI、JIYILIXIAJIANG、SIWEIHUNLUANDENG,DUOWEIFEIYANZHONG、KENIXINGFANYING,YIBANTINGYAOHOUJIKEHUIFU。

实验室检查发现 血清转氨酶显著和持续性升高的情况罕有报道。曾报道过碱性磷酸酶和γ-谷氨酸转肽酶升高的情况。肝功能检查异常为轻微和一过性的。 

LAIYUANYUGUGEJIDEXUEQINGJISUANJIMEI(CK)SHENGGAODEQINGKUANGYIYOUBAODAO(JIANZHUYISHIXIANG)。TATINGLEIYAOPINDESHANGSHIHOUJIANCEZHONGYOUGAOXUETANGFANYING、TANGNAILIANGYICHANG、TANGHUAXUEHONGDANBAISHUIPINGSHENGGAO、XINFATANGNIAOBING、XUETANGKONGZHIEHUADEBAOGAO,BUFENTATINGLEIYAOPINYIYOUDIXUETANGFANYINGDEBAOGAO。DUIYUXINFATATING,YOUSHENGGAOTANGHUAXUEHONGDANBAIHEKONGFUXUETANGDEBAOGAO。

儿童患者(年龄10~17岁) 在一项包括年龄10~17岁的儿童杂合子家族性高胆固醇血症患者的研究中(n=175),辛伐他汀治疗组的安全性和耐受性总体与安慰剂治疗组类似(见注意事项;儿童用药)。

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU:【JINJI】

OUZHOUBEIXIAZHU:---DUIBENPINRENHECHENGFENGUOMINZHE。

OUZHOUBEIXIAZHU:---HUODONGXINGGANZANGJIBINGHUOWUFAJIESHIDEXUEQINGZHUANANMEICHIXUSHENGGAOZHE。

OUZHOUBEIXIAZHU:---HUAIYUNHEBURUQIFUNV(JIANZHUYISHIXIANG、HUAIYUNHEBURUQIFUNVYONGYAO)。

---YUQIANGCYP3A4YIZHIJILIANHEYINGYONG(LIRU,YIQUKANGZUO、TONGKANGZUO、BOSHAKANGZUO、FULIKANGZUO、HIVDANBAIMEIYIZHIJI、BOPURUIWEI、TILARUIWEI、HONGMEISU、KELAMEISU、TAILIMEISU、NAIFAZUOTONGHUOHANYOUcobicistatDEYAOWU)(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIEYIJIYAOWUXIANGHUZUOYONG)。---YUJIFEIBEIQI、HUANBAOJUNSUHUODANEIZUOLIANHEYINGYONG(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIEYIJIYAOWUXIANGHUZUOYONG)。

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU:【ZHUYISHIXIANG】

肌病/横纹肌溶解 辛伐他汀偶尔能引起肌病,表现为肌肉痛、触痛或乏力,并伴随肌酸激酶(CK)升高,超过正常上限的10倍。肌病有时形成横纹肌溶解,伴或不伴继发于肌红蛋白尿的急性肾功能衰竭,由此发生的致命性事件罕见。血浆中HMG-CoA还原酶抑制剂水平很高时肌病的危险增加(即辛伐他汀与辛伐他汀酸的血药浓度升高),部分原因可能是相互作用的药物干扰辛伐他汀代谢和/或转运途径(见药物相互作用)。可预知的引起肌病的因素包括老龄(≥65岁),女性,未控制的甲状腺机能减退及肾功能不全。肌病/横纹肌溶解的风险与剂量相关。在一个临床试验数据库中,有41413名患者接受了辛伐他汀治疗。这些研究中有24747人(约为60%)中位随访期为至少4年,20,40和80mg/天的肌病发生率分别约为0.03%,0.08%和0.61%。

OUZHOUBEIXIAZHU: 

ZAIZHEIXIESHIYANZHONG,DUIHUANZHEJINXINGLEZIXIDEJIANCE,BINGPAICHULEMOUXIEXIANGHUZUOYONGDEYAOPIN。ZAIYIXIANGLINCHUANGSHIYANZHONG,GONGRUXUAN12064MINGXINJIGENGSIBINGSHIDEHUANZHE,PINGJUNSUIFANG6.7NIAN,JIESHOUXINFATATING80mg/TIANZHILIAOJIBINGDEFASHENGLVYUEWEI1.0%,ERJIESHOU20mg/TIANDEHUANZHEZEWEI0.02%。HENGWENJIRONGJIEDEFASHENGLV,JIESHOUXINFATATING80mg/TIANZHILIAODEHUANZHEFASHENGLVYUEWEI0.4%,ERJIESHOU20 mg/TIANDEHUANZHEZEWEI0%。YUEYOUBANSHUDEJIBINGBINGLI,SHIZAIZHILIAODEDI1NIANZHONGFASHENGDE。ZAIYIHOUZHILIAODEMEI1NIANZHONG,JIBINGDEFASHENGLVYUEWEI0.1%。JIESHOUXINFATATING80mgDEHUANZHE,YUJIESHOUJUYOUXIANGSIDELDL-CJIANGDIXIAOYINGDEYIQITATATINGLEIWEIJICHUDEZHILIAOXIANGBI,JIBINGDEFENGXIANJIAOGAO。YINGXIANGSUOYOUKAISHIXINFATATINGZHILIAODEHUANZHE,HUOZHENGZAIZENGJIAXINFATATINGJILIANGDEHUANZHETIXINGBAOKUOHENGWENJIRONGJIEZAINEIDEJIBINGDEFENGXIAN,BINGQIEGAOZHITAMENYINGJISHIBAOGAORENHEYUANYINBUMINGDEJIROUTONG、CHUTONGHUOJIWULI。RUGUOZHENDUANHUOHUAIYIJIBING,YINGLIJITINGYONGXINFATATING。

欧洲杯下注:

CHUXIANZHEIXIEZHENGZHUANG,BINGQIECKSHUIPINGCHAOGUO10BEIZHENGCHANGSHANGXIAN,BIAOMINGFASHENGLEJIBING。ZAIDADUOSHUBINGLIZHONG,DANGHUANZHEJISHITINGYONGZHILIAOSHI,JIROUZHENGZHUANGHECKSHENGGAOKEYIDEDAOHUANJIE(JIANBULIANGFANYING)。ZAIKAISHIXINFATATINGZHILIAOHUOZHENGZAIZENGJIAJILIANGDEHUANZHEZHONG,KEKAOLVDINGQICEDINGCK。ZHEIZHONGJIANCEBINGBUYIDINGKEYIYUFANGJIBING。ZAIXINFATATINGZHILIAOQIJIANFASHENGHENGWENJIRONGJIEDEHUANZHE,DUOSHUJUYOUFUZADEBINGSHI。ZHEIXIEBINGSHIZHONGBAOKUOSHENGONGNENGBUQUAN-TONGCHANGSHIYOUZHANGQIDETANGNIAOBINGDAOZHIDE。DUICILEIHUANZHEYINGJINXINGGENGWEIYANMIDEJIANCE。ZAIXINGZEQIDASHOUSHUZHIQIANHERENHEYANZHONGDENEIKEHUOWAIKEJIBINGFASHENGDEQINGKUANGXIA,XINFATATINGZHILIAOKEYIZANTINGJITIAN。ZAIYIXIANGLINCHUANGSHIYANZHONG,CHUYUGAOXINXUEGUANJIBINGFENGXIANDEHUANZHEJIESHOU40mg/RIXINFATATING(ZHONGWEISUIFANGQIWEI3.9NIAN)ZHILIAO,JIEGUOBIAOMING,FEIZHONGGUOYIHUANZHE(n=7367)ZHONGJIBINGFASHENGLVYUEWEI0.05%,YUZHIXIANGBI,ZHONGGUOYIHUANZHE(n=5468)DEFASHENGLVWEI0.24%。

RANER,ZHEIXIANGLINCHUANGSHIYANZAIYAYIQUNTIZHONGZHIPINGGULEZHONGGUOYIHUANZHE,YINCI,ZAIKAIJUXINFATATINGCHUFANGJIYAYIHUANZHESHIYINGGAISHENZHONG,BINGYINGCAIYONGZUIDIDEBIYAOJILIANG。

欧洲杯下注:

药物相互作用

OUZHOUBEIXIAZHU:XINFATATINGYUXIALIEYAOWULIANHEYINGYONGKEZENGJIAJIBING/HENGWENJIRONGJIEDEWEIXIAN:JINJILIANHEYINGYONGDEYAOWU

CYP3A4QIANGYIZHIJI:JINZHILIANHEYINGYONGSHUOMINGSHUSHANGLIEJUDEZAIZHILIAOJILIANGXIADUICYP3A4JUYOUQIANGYIZHIZUOYONGDEYAOWU(LIRU,YIQUKANGZUO、TONGKANGZUO、BOSHAKANGZUO、FULIKANGZUO、HONGMEISU、KELAMEISU、TAILIMEISU、HIVDANBAIMEIYIZHIJI、BOPURUIWEI、TILARUIWEI、NAIFAZUOTONGHUOHANYOUcobicistatDEYAOWU)。RUGUODUANQINEIBUKEBIMIANDEXUYAOYINGYONGCYP3A4QIANGYIZHIJIZHILIAO,ZAICIZHILIAOQIJIANYAOZANTINGXINFATATINGZHILIAO(JIANJINJI;YAOWUXIANGHUZUOYONG) 。

OUZHOUBEIXIAZHU:JIFEIBEIQI,HUANBAOJUNSUHUODANEIZUO:XINFATATINGJINJIYUZHEIXIEYAOWUHEYONG(JIANJINJI;YAOWUXIANGHUZUOYONG)。

欧洲杯下注:

其他药物

 •FUXIDISUAN:YINGYONGFUXIDISUANZHILIAODEHUANZHETONGSHIYINGYONGXINFATATINGZHILIAOSHI,KENENGHUIZENGJIAFASHENGJIBING/HENGWENJIRONGJIEDEFENGXIAN。(JIANYAOWUXIANGHUZUOYONG,QITAYAOWUXIANGHUZUOYONG,YAODAIDONGLIXUE)。XINFATATINGZHILIAOQIJIANBUTUIJIANHEYONGFUXIDISUAN。DUINEIXIEXUYAOQUANSHENXINGSHIYONGFUXIDISUANDEBINGREN,YOUBIYAOKAOLVZAIZHENGGEFUXIDISUANYONGYAOQIJIANTINGYONGXINFATATING。ZAITESHUQINGKUANGXIA,XUYAOYANZHANGQUANSHENXINGSHIYONGFUXIDISUAN,LIRUWEILEZHILIAOYANZHONGDEGANRAN,YINGGAIJUTIFENXIMEIGEHUANZHEDEQINGKUANG,BINGZAIYANMIDEYILIAOJIANCEXIAKAOLVSHIFOUXUYAOXINFATATINGYUFUXIDISUANHEYONG。

•QITABEITELEI:ZAITONGSHICHUFANGCHUJIFEIBEIQIZHIWAIDEQITABEITELEIHEXINFATATINGSHIYINGJINSHEN,YINWEIZHEILIANGLEIYAOWUDANYONGSHIDOUNENGDAOZHIJIBING。ERLIANGZHELIANHEYINGYONGSHIJIBINGDEFENGXIANHUIZENGJIA。YINGDANGZIXIQUANHENGSHIYONGDEHUOYIYUFENGXIAN。

•ANDIANTONG、ANLVDIPINGHUOLEINUOQIN:LIANHEYINGYONGANDIANTONG、ANLVDIPINGHUOLEINUOQINDEHUANZHE,XINFATATINGDEJILIANGBUYINGCHAOGUOMEITIAN20mg。

•WEILAPAMI、DIERLIUZHUOHUOJUENAIDALONG:LIANHEYINGYONGWEILAPAMI、DIERLIUZHUOHUOJUENAIDALONGDEHUANZHE,XINFATATINGDEJILIANGBUYINGCHAOGUOMEITIAN10mg。

•LUOMEITAPAI:ZAIHoFHHUANZHEZHONGTONGSHIFUYONGLUOMEITAPAIHEXINFATATING,XINFATATINGDEJILIANGBUYINGCHAOGUOMEITIAN40mg(JIANYAOWUXIANGHUZUOYONG,QITAYAOWUXIANGHUZUOYONG)。

•CYP3A4ZHONGXIAOYIZHIJI:YINGYONGSHUOMINGSHUSHANGLIEJUDEDUICYP3A4YOUZHONGDENGYIZHIZUOYONGDEYAOWUDEHUANZHE,LIANHEYINGYONGXINFATATING,YOUQISHIJIAOGAOJILIANGDEXINFATATING, QIJIBINGDEFENGXIANZENGJIA。DANGXINFATATINGYUCYP3A4ZHONGXIAOYIZHIJIHEYONGSHI,YOUBIYAODUIXINFATATINGDEJILIANGJINXINGDIAOZHENG。

•RUXIANAINAIYAODANBAIYIZHIJI(BCRP):LIANHEYINGYONGBCRPYIZHIJISHI(LIRUelbasvirHEgrazoprevir),KEDAOZHIXINFATATINGXUEYAONONGDUDEZENGJIACONGERZENGJIAJIBINGDEFENGXIAN,YINCIYOUBIYAODUIXINFATATINGDEJILIANGJINXINGDIAOZHENG。SHANGWUXINFATATINGYUelbasvirHEgrazoprevirLIANHEYINGYONGDEYANJIUZILIAO;ZAILIANHEYINGYONGelbasvirHUOgrazoprevirDEHUANZHEZHONG,XINFATATINGDEJILIANGBUYINGCHAOGUOMEITIAN20mg(JIANYAOWUXIANGHUZUOYONG,QITAYAOWUXIANGHUZUOYONG)。

•YANSUAN(≥1g/TIAN):ZAIXINFATATINGYUDIAOZHIJILIANG(≥1g/TIAN)DEYANSUANLIANHEYINGYONGSHI,GUANCHADAOLEJIBING/HENGWENJIRONGJIEBINGLI。ZAIYIXIANGLINCHUANGSHIYAN(ZHONGWEISUIFANGQI3.9NIAN)ZHONG,CHUYUGAOXINXUEGUANJIBINGFENGXIANQIELDL-CSHUIPINGKONGZHILIANGHAODEHUANZHE,ZAILIANHEHUOBULIANHESHIYONG10mgYIZHEMAIBUDEQINGKUANGXIAJIESHOU40mg/RIXINFATATINGZHILIAO,JIEGUOBIAOMING,ZENGJIADIAOZHIJILIANG(≥1g/RI)DEYANSUANMEIYOUZENGJIAXINXUEGUANJIEJUDEHUOYI。YINCI,LIANHESHIYONGXINFATATINGYUYANSUANSHI,YINGDUILIANHESHIYONGDEHUOYIYUQIQIANZAIFENGXIANJINXINGZIXIQUANHENG。CIWAI,ZAIZHEIXIANGSHIYANZHONG,JIESHOUXINFATATING40mg HUOYIZHEMAIBUXINFATATING10/40mgZHILIAODEZHONGGUOYIHUANZHEDEJIBINGFASHENGLVYUEWEI0.24%,YUZHIXIANGBI,JIESHOUXINFATATING40mgHUOYIZHEMAIBUXINFATATING10/40mgYUHUANSHIYANSUANLALUOPILUN2g/40mgLIANHEZHILIAODEZHONGGUOYIHUANZHEDEJIBINGFASHENGLVWEI1.24%。RANER,ZHEIXIANGLINCHUANGSHIYANZAIYAYIQUNTIZHONGJINPINGGULEZHONGGUOYIHUANZHE,YOUYUZHONGGUOYIHUANZHEZHONGJIBINGFASHENGLVGAOYUFEIZHONGGUOYIHUANZHE,SUOYIBUTUIJIANBENPINYUDIAOZHIJILIANG(≥1g/RI)YANSUANLIANYONGZAIYAYIRENQUNZHONGDESHIYONG(JIANYAOWUXIANGHUZUOYONG,QITAYAOWUXIANGHUZUOYONG)。

肝功能损伤临床研究中,大约1%接受辛伐他汀治疗的成年患者出现血清转氨酶持续升高(高于正常值上限3倍)。这些患者间断或终止用药后,转氨酶水平通常缓慢地降低到治疗前水平。这种转氨酶升高不伴有黄疸或其他的症状或体征,没有过敏的表现,这些患者中的一部分人在辛伐他汀治疗前肝功能检查异常和/或饮用过大量的酒精。在北欧辛伐他汀生存研究中,整个研究期间有一种以上转氨酶升高超过正常值上限3倍的患者数,在辛伐他汀组和安慰剂组之间没有显著差异[14(0.7%):12(0.6%)]。

XINFATATINGZUSGPT(ALT)DANXIANGSHENGGAODADAOZHENGCHANGZHISHANGXIAN3BEIDECHUXIANPINLVZAIYANJIUDEDIYINIANZHONGMINGXIANJIAOGAO(20:8,P=0.023),DANCIHOUJIUBUZAIMINGXIAN。ZHUANANMEIDESHENGGAODAOZHIXINFATATINGZHILIAOZU(n=2221)ZHONG8MINGHUANZHEJIANWEIJIZU(n=2223)ZHONG5MINGHUANZHETINGYAO。4SYANJIUZHONG,YONGXINFATATINGZHILIAODE1986MINGHUANZHEZAIJIXIANSHIGANGONGNENGJIANCHA(LFTs)ZHENGCHANG,JINYOU8REN(0.4%)ZAI5.4NIAN(ZHONGWEISUIFANGQI)ZHONGZHUANANMEILIANXUCHAOGUOZHENGCHANGZHISHANGXIAN3BEIHE/HUOYOUYUZHUANANMEISHENGGAOERTINGYAO。CIYANJIUZHONGSUOYOUHUANZHEXINFATATINGDEQISHIJILIANGJUNWEI20mg,QIZHONG37%DEHUANZHEZAIZHILIAOGUOCHENGZHONGDIAOZHENGDAO40mg。

ZAIBAOKUO1105MINGHUANZHEDE2XIANGDUIZHAOLINCHUANGYANJIUZHONG,RENWEIYUYAOWUYOUGUANDEGANZHUANANMEICHIXUSHENGGAO6GEYUEDEFASHENGLV,ZAI40mgHE80mgJILIANGZUFENBIEWEI0.7%HE1.8%。ZAIHPSYANJIUZHONG,20536MINGHUANZHEBEISUIJIFENPEIFUYONGXINFATATINGMEIRI40mgHUOANWEIJI,ZHUANANMEISHENGGAOCHAOGUOZHENGCHANGZHISHANGXIAN3BEIDEFASHENGLVZAIXINFATATINGZUHEANWEIJIZUFENBIEWEI0.21%HE0.09%。JIANYIZAIZHILIAOKAISHIQIANHESUIHOUDEYOULINCHUANGZHIZHENGSHIJINXINGGANGONGNENGJIANCHA。YINGTEBIEZHUYICHUXIANXUEQINGZHUANANMEISHENGGAODEHUANZHE,DUIZHEIXIEHUANZHEYINGJISHIZHONGFUCEDINGBINGYUCIHOUZENGJIAGANGONGNENGJIANCHADEPINLV。RUGUOZHUANANMEISHUIPINGBIAOXIANWEISHANGSHENGQUSHI,YOUQISHIZHUANANMEIZHISHANGSHENGDAOZHENGCHANGZHISHANGXIAN3BEIBINGCHIXUBUJIANGSHI,YINGTINGYAO。YINGZHUYIBINGANSUANZHUANANMEIKENENGLAIZIJIROU,YINCIBINGANSUANZHUANANMEIBANSUIJISUANJIMEISHENGGAO,YOUKENENGTISHIJIBING(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。

XIANZAIYIYOUJISHAOSHUGUANYUHUANZHEYINGYONGTATINGLEI,BAOKUOBENPIN,FASHENGZHIMINGHEFEIZHIMINGDEGANSHUAIJIEDESHANGSHIHOUBAOGAO。JIARUZAIYINGYONGBENPINZHILIAOQIJIANFASHENGYANZHONGDEGANSUNSHANGBANSUILINCHUANGZHENGZHUANG,HE/HUOGAODANHONGSUXUEZHENG,HUOFASHENGHUANGDAN,LIJITINGZHIYINGYONGBENPIN。RUGUOMEIYOUZHAODAOZHIBINGYUAN,BUYAOZAIZHONGXINYINGYONGBENPIN。DUIYINYONGDALIANGJIUJINGHE/HUOYOUJIWANGGANZANGBINGSHIDEHUANZHE,YINGJINSHENSHIYONGGAIYAO。XINFATATINGJINYONGYUHUODONGXINGGANZANGJIBINGHUOYUANYINBUMINGDEZHUANANMEISHENGGAODEHUANZHE。YUQITAJIANGZHIYAOYIYANG,XINFATATINGZHILIAOHOUYOUXUEQINGZHUANANMEIZHONGDU(DIYUZHENGCHANGSHANGXIANDE3BEI)SHENGGAODEBAODAO。ZHEIXIEBIANHUAZAIXINFATATINGZHILIAOKAISHIHOUHENKUAICHUXIAN,DANWANGWANGSHIZANSHIDE,BUBANYOURENHEZHENGZHUANGBINGQIEBUXUYAOZHONGDUANZHILIAO。

YANKEJIANCHAJISHIZAIMEIYOURENHEYAOWUZHILIAOSHI,SUIZHENIANLINGDEZENGZHANGJINGZHUANGTIHUNZHUODEFABINGLVYEHUIZENGJIA。ZHANGQILINCHUANGYANJIUZILIAOXIANSHI,XINFATATINGDUIRENDEJINGZHUANGTIWUBULIANGYINGXIANG。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YUNFUJIBURUQIFUNVYONGYAO】

RENSHENQIFUNV RENSHENQIFUNVJINYONGBENPIN。SHANGWEIYOURENSHENQIFUNVFUYONGXINFATATINGDEANQUANXINGSHUJU。ZAIRENSHENFUNVZHONGSHANGWEIJINXINGXINFATATINGDEDUIZHAOLINCHUANGSHIYAN。YOUYUZAIYUNQISHIYONGHMG-CoAERDAOZHIDEXIANTIANQUEXIANYEHENSHAOYOUBAODAO。DANSHI,ZAIDUIDAYUE200MINGYUNQIDEQIANSANGEYUESHIYONGGUOXINFATATINGHUOQITAMIQIEXIANGGUANDEHMG-CoAYIZHIJIDEHUANZHEHUIGUXINGFENXISHIFAXIAN,XIANTIANQUEXIANDEFASHENGLVYUPUTONGRENQUNXIANGSI。ZHEIZHONGHUIGUDEHUANZHESHUZAITONGJIXUESHANGYIJINGNENGGOUPAICHUXIANTIANQUEXIANDEFASHENGLVBUGAOYUPUTONGFASHENGDE2.5BEIHUOGENGGAO。

JINGUANMEIYOUMINGQUEDEZHENGJUNENGSHUOMINGHUAIYUNFUNVSHIYONGXINFATATINGHUIZAOCHENGXIANTIANQUEXIANFASHENGZENGDUO,DANSHIXINFATATINGNENGJIANGDITAIERDEJIAQIANGWUSUAN(DANGUCHUNSHENGWUHECHENGDEQIANTI)SHUIPING。DONGMAIZHOUYANGYINGHUASHIMANXINGGUOCHENG,SUOYIRENSHENQITINGYONGJIANGZHIYAODUIZHILIAOYUANFAXINGGAODANGUCHUNXUEZHENGDEZHANGQIXIAOGUOYINGXIANGSHENXIAO。YINCIRENSHENQIFUNV、ZHUNBEIHUAIYUNHUOKENENGHUAIYUNDEFUNVJINYONGBENPIN。ZAIHUAIYUNQIJIANYINGZANTINGSHIYONGBENPIN(JIANJINJI)。BURUQIFUNV MUQIANHAIBULEJIEXINFATATINGJIQIDAIXIECHANWUSHIFOUJINGRENRUFENMI,YINWEIXUDUOYAOWUJINGRENRUFENMIQIEKENENGYINQIDEYANZHONGBULIANGFANYING,FUYONGBENPINDEFUNVBUYIBURU(JIANJINJI)。

欧洲杯下注:

OUZHOUBEIXIAZHU:【ERTONGYONGYAO】

XINFATATINGZAINIANLING10~17SUIDEZAHEZIJIAZUXINGGAODANGUCHUNXUEZHENGHUANZHEZHONGDEANQUANXINGHEYOUXIAOXINGYIZAIYIGEZAIQINGCHUNQINANHAIHENVHAI(ZHISHAOCHUCHAO1NIANHOU)ZHONGJINXINGDEDUIZHAOSHIYANDEDAOPINGJIA。XINFATATINGZHILIAOZUHUANZHEDEBULIANGSHIJIANZONGTIYUANWEIJIZULEISI。ZAICIRENQUNZHONGWEIJINXINGJILIANGDAYU40mgDEYANJIU。ZAIZHEIGEYOUXIANDEDUIZHAOYANJIUZHONG,WEIFAXIANXINFATATINGDUIQINGCHUNQINANXINGHUONVXINGDESHENGZHANGHUOXINGCHENGSHUYOUMINGXIANDEYINGXIANG,HUODUIQINGCHUNQINVXINGDEYUEJINGZHOUQIZHANGDUYOUYINGXIANG(JIANYONGFAYONGLIANG;BULIANGFANYING)。JIANYIQINGCHUNQINVXINGXINFATATINGZHILIAOSHICAIYONGSHIDANGDEBIYUNFANGFA(JIANJINJI;ZHUYISHIXIANG;YUNFUJIBURUQIFUNVYONGYAO)。WEIZAINIANLINGXIAOYU10SUIDEHUANZHEJIYUEJINGCHUCHAOQIANDENVHAIZHONGJINXINGXINFATATINGDEYANJIU。

欧洲杯下注:

OUZHOUBEIXIAZHU:【LAONIANYONGYAO】

ZAILAONIANHUANZHE(>65SUI)YINGYONGXINFATATINGDEDUIZHAOLINCHUANGYANJIUZHONG,QIJIANGDIZONGDANGUCHUNHEDIMIDUZHIDANBAIDANGUCHUNDEXIAOGUOYUQITARENQUNDEJIEGUOXIANGSI,BULIANGFANYINGHESHIYANSHIJIANCHAYICHANGDEZONGFASHENGLVYEWUMINGXIANZENGDUO。RANER,ZAIYIXIANGHUANZHEJIESHOU80mg/TIANXINFATATINGZHILIAODELINCHUANGSHIYANZHONG,65SUIJIYISHANGDEHUANZHEFASHENGBAOKUOHENGWENJIRONGJIEZAINEIDEJIBINGDEFENGXIANXIANGDUIGAOYU65SUIYIXIADEHUANZHE。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAOWUXIANGHUZUOYONG】

DUOZHONGJIZHIKENENGYINQIYUHMG-CoAHAIYUANMEIYIZHIJIZHIJIANQIANZAIDEXIANGHUZUOYONG。YIZHIMOUXIEMEI(RUCYP3A4)HE/HUOZHUANYUNDANBAI(RUOATP1B)TONGLUDEYAOWUHUOCAOYAOCHANPINKENENGHUISHIXINFATATINGHEXINFATATINGSUANDEXUEYAONONGDUSHENGGAO,DAOZHIJIBING/HENGWENJIRONGJIEDEFENGXIANZENGJIA。CHAYUESUOYOULIANHEYONGYAODECHUFANGXINXIYIHUOQUYUXINFATATINGQIANZAIDEXIANGHUZUOYONGHE/HUOMEI、ZHUANYUNJIZHIDEBIANHUAYIJIJIYAOJILIANGHEFANGANDIAOZHENGDEGENGDUOXINXI。

欧洲杯下注:

OUZHOUBEIXIAZHU:YAOWUJINJI

JINJILIANHEYINGYONGYIXIAYAOWU:CYP3A4QIANGYIZHIJI:XINFATATINGTONGGUOCYP3A4DAIXIEDANMEIYOUCYP3A4YIZHIHUOXING;YINCITABUHUIYINGXIANGTONGGUOCYP3A4DAIXIEDEQITAYAOWUDEXUEJIANGNONGDU。QIANGXIAOCYP3A4YIZHIJI(RUXIA)TONGGUOJIANSHAOXINFATATINGDEXIAOCHUERZENGJIAJIBINGDEWEIXIAN。JINZHILIANHEYINGYONGSHUOMINGSHUSHANGLIEJUDEDUICYP3A4 JUYOUQIANGYIZHIZUOYONGDEYAOWU(LIRU,YIQUKANGZUO,TONGKANGZUO,BOSHAKANGZUO,FULIKANGZUO,HONGMEISU,KELAMEISU,TAILIMEISU,HIVDANBAIMEIYIZHIJI,BOPURUIWEI、TILARUIWEI、NAIFAZUOTONGHUOHANYOUcobicistatDEYAOWU)HEYONG(JIANJINJI;ZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。JIFEIBEIQI,HUANBAOJUNSUHUODANEIZUO: JINZHIYUXINFATATINGLIANHESHIYONG(JIANJINJI;ZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。

欧洲杯下注:

OUZHOUBEIXIAZHU:QITAYAOWUXIANGHUZUOYONG

QITABEITELEI:LIANHEYINGYONGCHUJIFEIBEIQIZHIWAIDEQITABEITELEIHUIZENGJIAJIBINGDEFENGXIAN;LIANHESHIYONGSHIYINGDANGJINSHENQUANHENGHUOYIYUFENGXIAN。ANDIANTONG:ANDIANTONGYUXINFATATINGLIANHEYINGYONGSHI, JIBING/HENGWENJIRONGJIEDEFENGXIANKENENGHUIZENGJIA (JIANYONGFAYONGLIANG;ZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。GAITONGDAOZUZHIJI:WEILAPAMI、DIERLIUZHUOHUOANLVDIPINGHEXINFATATINGLIANHEYINGYONGSHI,JIBING/HENGWENJIRONGJIEDEFENGXIANKENENGHUIZENGJIA(JIANYONGFAYONGLIANG;ZHUYISHIXIANG;JIBING/HENGWENJIRONGJIE)。LUOMEITAPAI:LIANHEYINGYONGLUOMEITAPAIHEXINFATATINGDEHUANZHE,QIJIBING/HENGWENJIRONGJIEFASHENGDEWEIXIANXINGKENENGHUIZENGJIA(YONGFAYONGLIANG;ZHUYISHIXIANG,YAOWUXIANGHUZUOYONG)。

欧洲杯下注:

CYP3A4ZHONGXIAOYIZHIJI:YINGYONGSHUOMINGSHUSHANGLIEJUDEDUICYP3A4YOUZHONGDENGYIZHIZUOYONGDEYAOWUDEHUANZHE,LIANHEYINGYONGXINFATATING,YOUQISHIJIAOGAOJILIANGDEXINFATATING,QIJIBINGFASHENGDEWEIXIANXINGKENENGHUIZENGJIA。OATP1B1ZHUANYUNDANBAIYIZHIJI:XINFATATINGSUANSHIOATP1B1ZHUANYUNDANBAIDEDIWU。YUOATP1B1ZHUANYUNDANBAIYIZHIYAOWULIANHEYINGYONGSHI,KENENGYINQIXINFATATINGSUANDEXUEJIANGNONGDUSHENGGAO,ZENGJIAJIBINGDEFENGXIAN。RUXIANAINAIYAODANBAIYIZHIJI(BCRP):XINFATATINGSHIWAIPAIXINGZHUANYUNTIBCRPDEDIWU,LIANHEYINGYONGBCRPYIZHIJISHI(LIRUelbasvirHEgrazoprevir),JIANGDAOZHIXINFATATINGXUEYAONONGDUDEZENGGAOCONGERZENGJIAJIBINGFENGXIAN。

欧洲杯下注:

ZAILIANHEYINGYONGXINFATATINGYUelbasvirHUOgrazoprevirDEHUANZHEZHONG,YOUBIYAODIAOZHENGXINFATATINGDEJILIANG(JIANYONGFAYONGLIANG;ZHUYISHIXIANG,QITAYAOWU)。YANSUAN(≥1g/TIAN):ZAIXINFATATINGYUDIAOZHIJILIANGDEYANSUAN(≥1g/TIAN)LIANHESHIYONGZHONGGUANCHADAOLEJIBING/HENGWENJIRONGJIEDEBINGLI(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。FUXIDISUAN:LIANHEYINGYONGFUXIDISUANKENENGHUIZENGJIAJIBING/HENGWENJIRONGJIEDEFENGXIAN(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE;YAODAIDONGLIXUE)。QIUSHUIXIANJIAN:YOUBAOGAOXIANSHI, ZAISHENGONGNENGBUQUANDEHUANZHEZHONG,LIANHEYINGYONGQIUSHUIXIANJIANHEXINFATATINGHUIYINQIJIBINGHEHENGWENJIRONGJIE。JIANYIDUILIANHEYINGYONGZHEIXIEYAOWUDEHUANZHE, JIYUMIQIELINCHUANGJIANCE。QITAXIANGHUZUOYONG PUTAOYOUZHIHANYOUYIZHONGHUODUOZHONGYIZHICYP3A4DECHENGFEN,NENGZENGJIAJINGCYP3A4DAIXIEDEYAOWUDEXUEJIANGSHUIPING。CHANGGUIYINYONGLIANG(MEIRIYIBEI250ml)SUOCHANSHENGDEYINGXIANGHENXIAO。

欧洲杯下注:

(TONGGUOCEDINGNONGDU-SHIJIANQUXIANXIAMIANJI,XUEJIANGHMG-CoAHAIYUANMEIYIZHIHUOXINGZENGJIALE13%)QIEWULINCHUANGYIYI。DANSHIJIAODALIANGDEYINYONGZEXIANZHUZENGJIAXUEJIANGHMG-CoAHAIYUANMEIYIZHIJIDEHUOXING,YINCI,ZAIXINFATATINGZHILIAOQIJIANYINGBIMIANYINYONGPUTAOYOUZHI(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。XIANGDOUSUYANSHENGWU ZAIYIXIANGJIANKANGZHIYUANZHEHELINGYIXIANGGAODANGUCHUNXUEZHENGHUANZHECANJIADELINCHUANGYANJIUZHONG,MEITIANFUYONGXINFATATING20~40mg,NENGZHONGDUTIGAOXIANGDOUSULEIKANGNINGJIDEKANGNINGXIAOGUO,YININGXUEMEIYUANSHIJIANGUOJIBIAOZHUNHUABILV(INR)JI,JIANKANGZHIYUANZHEZUDENINGXUEMEIYUANSHIJIANCONGJIXIANDE1.7YANZHANGDAO1.8MIAO,GAODANGUCHUNXUEZHENGHUANZHEZUCONG2.6YANZHANGDAO3.4MIAO。DUIYUSHIYONGXIANGDOUSUKANGNINGJIDEHUANZHE,YINGZAISHIYONGXINFATATINGZHIQIANCEDINGQININGXUEMEIYUANSHIJIAN,BINGZAIZHILIAOCHUQIJINGCHANGCELIANG,YIBAOZHENGNINGXUEMEIYUANSHIJIANWUMINGXIANBIANHUA。YIDANJILUXIAWENDINGDENINGXUEMEIYUANSHIJIAN,YINGJIANYIHUANZHEZAIFUYONGXIANGDOUSULEIKANGNINGJIQIJIANDINGQIJIANCENINGXUEMEIYUANSHIJIAN。RUDIAOZHENGXINFATATINGJILIANGHUOTINGYAO,YINGZHONGFUYISHANGBUZHOU。DUIYUWEIFUYONGXIANGDOUSULEIKANGNINGJIDEHUANZHE,CHUXUEHUONINGXUEMEIYUANSHIJIANBIANHUAYUFUYONGXINFATATINGWUGUAN。DIGAOXIN YIXIANGYANJIUFAXIAN,TONGSHIFUYONGDIGAOXINHEXINFATATINGSHIDIGAOXINDEXUEYAONONGDUQINGDUSHENGGAO。LIANHESHIYONGDIGAOXINHEXINFATATINGSHIYINGDANGJIANCEDIGAOXINXUEYAONONGDU。

欧洲杯下注:

【YAOWUGUOLIANG】YOUSHAOSHUFUYAOGUOLIANGDEBAODAO;ZUIDAFUYONGJILIANGWEI3.6g。SUOYOUHUANZHEJUNKANGFUQIEWUHOUYIZHENG。YIBANCAIQUCHANGGUICUOSHICHULIFUYAOGUOLIANG。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAOLIDULI】

YAOLIZUOYONG XINFATATINGSHIYIZHONGQIANYAO,JIYAOHOUSHUIJIEWEIHUOXINGXINGSHIβ-QIANGJISUAN,JIXINFATATINGSUAN。XINFATATINGSHITEYIXINGDEHMG-CoAHAIYUANMEIYIZHIJI,GAIMEIZUOWEIDANGUCHUNSHENGWUHECHENGDEXIANSUMEI,CUIHUAHMG-CoAZHUANHUAWEIJIAQIANGWUSUAN。XINFATATINGNENGJIANGDIXUEJIANGJIDIMIDUZHIDANBAI(VLDL)HEGANYOUSANZHI(TG)NONGDU,SHENGGAOXUEJIANGGAOMIDUZHIDANBAIDANGUCHUN(HDL-C)DENONGDU。

欧洲杯下注:

DULIYANJIU ZHONGSHUSHENJINGXITONG(CNS)DUXING:QUANJINGKOUJIYUXINFATATING180mg/kg/TIAN(JIYUBAOLUSHUIPINGTUISUAN,YUEWEIRENTIJILIANG80mg/TIANDE12BEIHUOGENGGAO),LIANXUJIYAO14ZHOU,KEJIANSHISHENJINGTUIHUA。QUANJINGKOUJIYUYUXINFATATINGHUAXUEXINGZHILEISIDEYAOWU60mg/kg/TIAN(JIYUZONGMEIYIZHIHUOXINGTUISUAN,YUEWEIRENZUIDATUIJIANJILIANGDE30BEIHUOGENGGAO),KEJIANSHISHENJINGTUIHUA(SHIWANGMO-XIZHUANGTI(SHENJING)XIANWEIDEHUALE(SHI)BIANXING),GAIXIAOYINGJUYOUJILIANGXIANGGUANXING。

欧洲杯下注:

QUANJINGKOUJIYUXINFATATING180mg/kg/TIAN,LIANXUJIYAO14ZHOU,KEJIANQIANTING(ER)WODEWallerian-likeYANGBIANZHIHESHIWANGMOSHENJINGJIEXIBAORANZHIRONGJIE, GAIJILIANGCHANSHENGDEPINGJUNXUEJIANGYAOWUSHUIPINGYUMEIRI60mg/kg/TIANJILIANGXIADESHUIPINGXIANGSI。

欧洲杯下注:

CNSXUEGUANXINGSUNHAI:QUANJINGKOUJIYUXINFATATINGJILIANGDA360mg/kg/TIAN(JIYUBAOLUSHUIPINGTUISUAN,YUEWEIRENTI80mg/TIANDE14BEIHUOGENGGAO),KEJIANXUEGUANZHOUWEICHUXUEHESHUIZHONG,XUEGUANZHOUXIDANHEXIBAOSHENTOU、XUEGUANZHOUXIXIANWEIDANBAICHENZHEHEXIAOXUEGUANHUAISI,TONGLEIYAOWUYEGUANCHADAOLEISIDECNSXUEGUANBINGBIAN。 CIXINGDASHUJINGKOUJIYUXINFATATING50HE100mg/kg/TIAN(JIYUBAOLUSHUIPINGTUISUAN,FENBIEYUEWEIRENTI80mg/TIANDE22HE25BEI),LIANXUJIYAO2NIAN;QUANJINGKOUJIYUXINFATATING90mg/kg/TIAN(19BEI)LIANXU3GEYUE,YIJI50mg/kg/TIAN(5BEI)LIANXU2NIAN,KEJIANDONGWUCHUXIANBAINEIZHANG。

欧洲杯下注:

YICHUANDUXING:XINFATATINGZAISHIYONGHUOWEISHIYONGDASHUHUOXIAOSHUGANZANGDAIXIEHUOHUADEWEISHENGWUZHITUBIANXING(Ames)SHIYAN、DASHUGANXIBAOYICHUANWUZHISUNSHANGSHIYAN、V-79BURUDONGWUXIBAOZHENGXIANGTUBIANSHIYANHECHOXIBAORANSETIJIBIANSHIYAN,YIJITINEIXIAOSHUWEIHESHIYANJIEGUOJUNWEIYINXING。

欧洲杯下注:

SHENGZHIDUXING:XIONGXINGDASHUZHONGFUJINGKOUJIYUXINFATATING25mg/kg,JIYAO34ZHOU,KEJIANSHENGYULIJIANGDI(JIYUBAOLUSHUIPINGTUISUAN,YUEWEIRENTI80mg/TIANDE4BEI),DANZAISUIHOUDEXIONGXINGDASHUZHONGFUJIYUXINFATATING25mg/kgDE11ZHOUDUXINGSHIYAN,GUANCHAZHIWANZHENGDEJINGZIZHOUQI,BAOKUOFUGAOCHENGSHU,WEIJIANDUISHENGYULIDEMINGXIANSUNSHANG,WEIJIANGAOWANMINGXIANZUZHIBINGLIXUEGAIBIAN,DANZAI180mg/kg(JIYUBAOLUSHUIPINGTUISUAN,YUEWEIRENTI80mg/TIANDE22BEI)KEJIANSHENGJINGXIAOGUANTUIHUA(HUAISIHESHENGJINGSHANGPIXIBAODIUSHI)。QUANZHONGFUJIYUXINFATATING10mg/kg(JIYUBAOLUSHUIPINGTUISUAN,YUEWEIRENTI80mg/TIANDE2BEI)KEJIANYAOWUXIANGGUANDEGAOWANWEISUO、JINGZISHENGCHENGJIANGDI、JINGMUXIBAOTUIHUA、JUXIBAOXINGCHENG,LINCHUANGXIANGGUANXINGSHANGBUMINGQUE。RENSHENDASHUHETUFENBIEJINGKOUJIYUXINFATATING25mg/kgHE10mg/kg(YUEWEIRENTIBAOLULIANGDE3BEI),WEIJIANPEITAI-TAIZISHENGZHANGFAYUMINGXIANYICHANG,DANQITAJIEGOULEISIDETATINGLEIYAOWUZAIKEJIANDASHUHETUDEZIDAIGUGEJIJIXING。DASHUJINGKOUJIYUXINFATATINGHUOXINGQIANGSUANHUADAIXIECHANWU60mg/kg/TIAN,KEJIANMUTITIZHONGXIAJIANG、PEITAIXISHOULVZENGJIAHEGUGEJIJIXINGZENGDUO。ZHIHOUDELEISISHIYANXIANSHI,PEITAIXISHOUHEGUGEJIJIXINGJINFASHENGYUNIECHILEIDONGWU,QIEYUMUTIDUXING(QIANWEISUNHAIBINGBANYOUTIZHONGXIAJIANG)YOUGUAN。

欧洲杯下注:

ZHIAIXING:XIAOSHUJINGKOUJIYUXINFATATING25、100HE400mg/kg/TIAN,JIYAO72ZHOU,PINGJUNXUEJIANGYAOWUSHUIPINGFENBIEYUEXIANGDANGYURENTIJILIANG80mg/TIANBAOLULIANGDE1、4HE8BEI,GANXIBAOAIZAIGAOJILIANGCIXINGHEZHONG、GAOJILIANGXIONGXINGDONGWUDEFABINGLVMOXINGSHENGGAO,QIZHONGZAIXIONGXINGDONGWUDEZUIGAOFABINGLVDA90%,ZHONG、GAOJILIANGZUCIXINGGANZANGXIANLIUDEFABINGLVMOXINGSHENGGAO,GAOJILIANGZUHADEXIAN(NIECHILEIDONGWUYANBUXIANTI)XIANLIUDEFABINGLVMOXINGSHENGGAO,WEIJIAN25mg/kgZUZHILIUZUOYONGDEZHENGJU。ZAIYIXIANGDULIDE92ZHOUXIAOSHUZHIAIXINGYANJIUZHONG,WEIGUANCHADAO25mg/kgZU(JIYUBAOLUSHUIPINGTUISUAN,YUEXIANGDANGYURENTI80mg/TIAN)ZHILIUZUOYONGDEZHENGJU。DASHU2NIANZHIAIXINGSHIYAN,25mg/kgJILIANGZUCIXINGDONGWU,JIAZHUANGXIANLVPAOXIBAOXIANLIUDEFABINGLVMINGXIANZENGJIA,BAOLUSHUIPINGYUEWEIRENTIJILIANG80mg/TIANBAOLULIANGDE11BEI。LINGYIXIANGDASHU2NIANZHIAIXINGSHIYAN,50HE100mg/kgJILIANGZUGANXIBAOXIANLIUHEGANXIBAOAIFASHENGLVZENGJIA(LIANGGEJILIANGZUDECIXINGDONGWUHEGAOJILIANGZUXIONGXINGDONGWUJUNCHUXIAN),LIANGGEJILIANGZUCIXIONGDONGWUJIAZHUANGXIANLVPAOXIBAOXIANLIUDEFABINGLVMINGXIANZENGJIA,100mg/kgJILIANGZUCIXINGDONGWUDEJIAZHUANGXIANLVPAOXIBAOAIFASHENGLVZENGJIA,YISHANGJIAZHUANGXIANZHONGLIUFASHENGLVZENGJIAYUTATINGLEIQITAYAOWUXIANGSI,FENBIEYUEWEIRENTI80mg/TIANXUEJIANGBAOLUSHUIPINGDE7BEIHE15BEI(XIONGXING)YIJI22BEIHE25BEI(CIXING)。 

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAODAIDONGLIXUE】

XINFATATINGJINGKOUFUHOUDUIGANZANGYOUGAODUDEXUANZEXING,QIZAIGANZANGZHONGDENONGDUMINGXIANGAOYUQITAFEIBAXINGZUZHI,XINFATATINGDEDABUFENZAIGANZANGJINXINGGUANGFANDESHOUGUOXISHOU,ZHUYAOZUOYONGZAIGANZANG,SUIHOUJINGDANZHIPAIXIE。ZHIYOUDIYU5%JILIANGDEXINFATATINGHUOXINGCHENGFENZAIWAIZHOUZHONGFAXIAN,ERQIZHONG95%KEYUXUEJIANGDANBAIJIEHE。YIXIANGYAODAIDONGLIXUESHIYANXIANSHI,TONGSHIFUYONGDIERLIUZHUODAOZHIXINFATATINGSUANDEBAOLULIANGZENGJIALE2.7BEI,TUICESHIYOUCYP3A4DEYIZHIZUOYONGYINQI(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。YIXIANGYAODAIDONGLIXUESHIYANXIANSHI,TONGSHIFUYONGANLVDIPINGDAOZHIXINFATATINGSUANDEBAOLULIANGZENGJIALE1.6BEI(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。YIXIANGYAODAIDONGLIXUESHIYANXIANSHI,2gDANJILIANGHUANSHIYANSUANYUXINFATATING20mgLIANYONGSHI,KEDAOZHIXINFATATINGHEXINFATATINGSUANDEAUCJIXINFATATINGSUANXUEJIANGNONGDUCmaxDESHENGGAO(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。FUXIDISUANZAIGANZANGDETEDINGDAIXIETUJINGSHANGBUQINGCHU, DANRENGHUAIYIFUXIDISUANHEJINGCYP3A4DAIXIEDEHMG-CoAHAIYUANMEIYIZHIJIYOUXIANGHUZUOYONG(JIANZHUYISHIXIANG,JIBING/HENGWENJIRONGJIE)。

欧洲杯下注:

OUZHOUBEIXIAZHU:【ZHU    ZANG】MIBI,ZAI30℃YIXIABAOCUN。

欧洲杯下注:

【BAO    ZHUANG】KOUFUGUTIYAOYONGGAOMIDUJUYIXIPING(1)10mg:10PIAN/PING,20PIAN/PING ;1PING/HE;(2)20mg:10PIAN/PING;1PING/HE;

欧洲杯下注:

OUZHOUBEIXIAZHU:【YOU XIAO QI】24GEYUE

欧洲杯下注:

OUZHOUBEIXIAZHU:【ZHIXINGBIAOZHUN】YBH05412020 

欧洲杯下注:

OUZHOUBEIXIAZHU:【PIZHUNWENHAO】10mg:GUOYAOZHUNZIH20065119  20mg:GUOYAOZHUNZIH20065120

欧洲杯下注:

OUZHOUBEIXIAZHU:【SHENGCHANQIYE】

OUZHOUBEIXIAZHU:  QIYEMINGCHENG:SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSI

OUZHOUBEIXIAZHU:  SHENGCHANDIZHI:SHANDONGSHENGLINYIGAOXINJISHUCHANYEKAIFAQULUOQILU

OUZHOUBEIXIAZHU:  YOUZHENGBIANMA:276017

OUZHOUBEIXIAZHU:  DIANHUAHAOMA:0539-8257899  8481991

OUZHOUBEIXIAZHU:  CHUANZHENHAOMA:0539-8481990

OUZHOUBEIXIAZHU:  SHOUHOUFUWU:0539-8242699

OUZHOUBEIXIAZHU:  WANG    ZHI:lastwordbookshop.com

OUZHOUBEIXIAZHU: 

OUZHOUBEIXIAZHU: 

高脂血症 

DUIYUYUANFAXINGGAODANGUCHUNXUEZHENGBAOKUOZAHEZIJIAZUXINGGAODANGUCHUNXUEZHENG、GAOZHIXUEZHENGHUOHUNHEXINGGAOZHIXUEZHENGDEHUANZHE,DANGYINSHIKONGZHIJIQITAFEIYAOWUZHILIAOBULIXIANGSHI,JIEHEYINSHIKONGZHI,BENPINKEYONGYUJIANGDISHENGGAODEZONGDANGUCHUN、DIMIDUZHIDANBAIDANGUCHUN、ZAIZHIDANBAIBHEGANYOUSANZHI,QIEKESHENGGAOGAOMIDUZHIDANBAIDANGUCHUN,CONGERJIANGDIDIMIDUZHIDANBAIDANGUCHUN/GAOMIDUZHIDANBAIDANGUCHUNJIZONGDANGUCHUN/GAOMIDUZHIDANBAIDANGUCHUNDEBILV。DUIYUCHUNHEZIJIAZUXINGGAODANGUCHUNXUEZHENGHUANZHE,JIEHEYINSHIKONGZHIJIFEIYINSHILIAOFA,BENPINKEYONGYUJIANGDISHENGGAODEZONGDANGUCHUN、DIMIDUZHIDANBAIDANGUCHUNHEZAIZHIDANBAIB。

欧洲杯下注:

冠心病 

DUIYUGUANXINBINGHEBINGGAODANGUCHUNXUEZHENGDEHUANZHE,BENPINSHIYONGYU:JIANGDISIWANGDEWEIXIANXING;JIANGDIGUANXINBINGSIWANGJIFEIZHISIXINGXINJIGENGSIDEWEIXIANXING;JIANGDIZUZHONGHEDUANZANXINGNAOQUEXUEDEWEIXIANXING;JIANGDIXINZANGXUEGUANZHONGJIANSHOUSHU(GUANZHUANGDONGMAIPANGLUYIZHISHUJIJINGPIQIANGNEIGUANZHUANGDONGMAICHENGXINGSHU)DEWEIXIANXING;YANHUANGUANZHUANGDONGMAIZHOUYANGYINGHUADEJINCHENG,BAOKUOJIANSHAOXINBINGZAOJIQUANDUSAIDEXINGCHENG。

欧洲杯下注:

患有杂合子家族性高胆固醇血症的儿童患者 

DUIYUHUANYOUZAHEZIJIAZUXINGGAODANGUCHUNXUEZHENGDE10~17SUIDEQINGCHUNQINANHAIHENVHAI(ZHISHAOCHUCHAO1NIANHOU),JIEHEYINSHIKONGZHI,BENPINKEYONGYUJIANGDIZONGDANGUCHUN、DIMIDUZHIDANBAIDANGUCHUN、GANYOUSANZHIHEZAIZHIDANBAIB。

欧洲杯下注:

OUZHOUBEIXIAZHU:HUANZHEJIESHOUBENPINZHILIAOYIQIAN,YINGJIESHOUBIAOZHUNDEJIANGDANGUCHUNYINSHIBINGZAIZHILIAOGUOCHENGZHONGJIXUWEICHI。

欧洲杯下注:

TUIJIANJILIANGFANWEIWEIMEITIAN5~40mg,WANJIANYICIFUYONG,SUOYONGJILIANGYINGGENJUJICHUDIMIDUZHIDANBAIDANGUCHUNSHUIPING、TUIJIANDEZHILIAOMUBIAOHEHUANZHEFANYINGJINXINGGETIHUADIAOZHENG。DIAOZHENGJILIANGYINGJIANGE4ZHOUHUOYISHANG。TUIJIANDEQISHIJILIANGWEIMEITIAN10mgHUO20mg,WANJIANYICIFUYONG。DUIYUYINCUNZAIGUANXINBING、TANGNIAOBING、ZHOUWEIXUEGUANJIBING、ZUZHONGHUOQITANAOXUEGUANJIBINGSHIERSHUYUCHDSHIJIANGAOWEIRENQUNDEHUANZHE,TUIJIANDEQISHIJILIANGWEI20~40mg/TIAN。DUIYUZHIXUZHONGDUJIANGDIDIMIDUZHIDANBAIDANGUCHUNDEHUANZHE,QISHIJILIANGWEI10mg。----XIANZHI80mg/TIANJILIANGDESHIYONG XINFATATINGKEZENGJIAJIBINGBAOKUOHENGWENJIRONGJIEDEFENGXIAN(TEBIESHIZAIYONGYAODEDIYINIANNEI)。JIYUSHANGSHUFENGXIAN,DUIYU40mg/TIANJILIANGWEINENGSHIDIMIDUZHIDANBAIDANGUCHUNDABIAODEHUANZHE,BUYINGZAIZENGJIAJIYAOJILIANG,ERYINGZHUANHUANWEIQITALIAOXIAOGENGQIANGDELIAOFA。DUIYUYUANLAIZHENGZAISHIYONGXINFATATING80mgQIEWUANQUANXINGWENTIDEHUANZHE,RUGUOXUYAOKAISHISHIYONGYUXINFATATINGYOUXIANGHUZUOYONGDEYAOWU,ERGAIYAOWUJINZHIYUXINFATATINGHEYONG,HUOZHEHEYONGGAIYAOWUSHIDUIXINFATATINGDEJILIANGYOUXIANZHI,ZEYINGDANGJIANGBENPINZHUANHUANWEIYAOWUXIANGHUZUOYONGKENENGXINGJIAODIDEQITATATINGLEIYAOWU。YOUYUZENGJIAJIBINGBAOKUOHENGWENJIRONGJIEDEFENGXIAN,BENPIN80mgJILIANGJINXIANYONGYUJIWANGYIJINGZHANGQISHIYONG(≥1NIAN)XINFATATING80mgJILIANG,BINGQIEBUCUNZAIJIROUDUXINGZHENGJUDEHUANZHE。----HEBINGSHIYONGQITAYAOWU TONGSHIFUYONGWEILAPAMI、DIERLIUZHUOHUOJUENAIDALONG:BENPINDEJILIANGBUNENGCHAOGUO10mg/TIAN;TONGSHIFUYONGANDIANTONG、ANLVDIPING、LEINUOQINHUOHANYOUelbasvir、grazoprevirDEYAOWU:BENPINDEJILIANGBUNENGCHAOGUO20mg/TIAN。

欧洲杯下注:

OUZHOUBEIXIAZHU:----CHUNHEZIJIAZUXINGGAODANGUCHUNXUEZHENG 

GENJUYIXIANGDUIZHAOLINCHUANGYANJIUDEJIEGUO,DUIYUCHUNHEZIJIAZUXINGGAODANGUCHUNXUEZHENGHUANZHE,BENPINDETUIJIANJILIANGWEIMEITIAN40mg,WANJIANYICIFUYONG。BENPINKEYUQITAJIANGZHILIAOFALIANHEYINGYONG(RUDIMIDUZHIDANBAIXUEJIANGFENLIZHIHUANFA),DANGWUFASHIYONGZHEIXIEFANGFASHI,KEDANDUSHIYONGBENPIN。TONGSHIFUYONGLUOMEITAPAI,BENPINDEJILIANGBUNENGCHAOGUO40mg/TIAN。

欧洲杯下注:

OUZHOUBEIXIAZHU:----SHENGONGNENGBUQUANDEHUANZHE 

YOUYUBENPINJINGSHENZANGPAIXIEBUMINGXIAN,GUQING、ZHONGDUSHENGONGNENGBUQUANHUANZHEBUXUDIAOZHENGJILIANG。RANER,DUIYUYANZHONGSHENGONGNENGBUQUANDEHUANZHE(JIGANQINGCHULV<30ml/FENZHONG)YINGSHENYONGBENPIN,CILEIHUANZHEDEQISHIJILIANGYINGWEIMEITIAN5mg,BINGMIQIEJIANCE。

欧洲杯下注:

OUZHOUBEIXIAZHU:----ZAHEZIJIAZUXINGGAODANGUCHUNXUEZHENGERTONGHUANZHE(10~17SUI)

DUIZAHEZIJIAZUXINGGAODANGUCHUNXUEZHENG10~17SUIDEERTONGHUANZHE,BENPINTUIJIANDEQISHIJILIANGWEIMEITIAN10mg,WANJIANYICIFUYONG。TUIJIANDEJILIANGFANWEIWEIMEITIAN10~40mg,TUIJIANDEZUIDAJILIANGWEIMEITIAN40mg。SUOYONGJILIANGYINGGENJUTUIJIANDEZHILIAOMUBIAOJINXINGGETIHUADIAOZHENG。

欧洲杯下注:

OUZHOUBEIXIAZHU:----ZHONGGUOHUANZHESHIYONGDIAOZHIJILIANGDEYANSUANHUOHANYANSUANYAOWU 

ZHONGGUOHUANZHEHEBINGSHIYONGXINFATATING40mg/TIANYUDIAOZHIJILIANGDEYANSUANHUOHANYANSUANYAOWUSHI,JIBINGFENGXIANZENGGAO,YINCI,ZHONGGUOHUANZHEHEBINGSHIYONGCHAOGUO20mgJILIANGDEXINFATATINGYUDIAOZHIJILIANGDEYANSUANHUOHANYANSUANYAOWUYAOJINSHEN。YINWEIJIBINGDEFENGXIANYUJILIANGJUYOUXIANGGUANXING,ZHONGGUOHUANZHEBUYINGHEBINGSHIYONG80mgJILIANGXINFATATINGYUDIAOZHIJILIANGDEYANSUANHUOHANYANSUANYAOWU。ZHONGGUOHUANZHEJIBINGFENGXIANZENGJIADEYUANYINSHANGBUMINGQUE。SHANGBUQINGCHUZAIQITAYAYIHUANZHEZHONG,LIANHEYINGYONGSHIFOUHUIDAOZHIJIBINGDEFENGXIANZENGJIA。

欧洲杯下注:

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