欧洲杯下注

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JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

JIANKUCHUANGYE、CHENGXINWEIBEN、KAITUOCHUANGXIN、YANXISHOUJI

SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSIZHAOBIAOGONGGAO

心血管疾病

西洛他唑片

【GUI   GE】 50mg

【BAO   ZHUANG】LVSUBAOZHUANG;6PIAN/BAN、8PIAN/BAN、10PIAN/BAN、12PIAN/BAN;1BAN/HE、2BAN/HE。

【DAN   WEI】PIAN

【PIZHUNWENHAO】《ZHONGGUOYAODIAN》2015NIANBANDIYIZENGBUBEN


分享:
  • 药品介绍
  • 适应症
  • 用法用量

OUZHOUBEIXIAZHU:【YAOPINMINGCHENG】

OUZHOUBEIXIAZHU:     TONGYONGMINGCHENG:XILUOTAZUOPIAN

OUZHOUBEIXIAZHU:     YINGWENMINGCHENG:Cilostazol Tablets

OUZHOUBEIXIAZHU:     HANYUPINYIN:Xiluotazuo Pian

欧洲杯下注:

OUZHOUBEIXIAZHU:【CHENG    FEN】 BENPINZHUYAOCHENGFENWEIXILUOTAZUO。

     HUAXUEMINGCHENG:6-[4-(1-HUANJIJI-1H-SIDANZUO-5-JI)DINGYANGJI]-3,4-ERQING-2(1H)-KUINUOTONG。

OUZHOUBEIXIAZHU:     HUAXUEJIEGOUSHI:

欧洲杯下注:

                             1.jpg

     分子式:C20H27N5O2

OUZHOUBEIXIAZHU:     FENZILIANG:369.47

欧洲杯下注:

OUZHOUBEIXIAZHU:【XING    ZHUANG】 BENPINWEIBAISEHUOLEIBAISEPIAN。

欧洲杯下注:

OUZHOUBEIXIAZHU:【GUI    GE】 50mg

欧洲杯下注:

OUZHOUBEIXIAZHU:【BULIANGFANYING】

     1.  QUANSHENBULIANGFANYING:FUTONG、BEITONG、TOUTONG、GANRAN、SHUIZHONG。

OUZHOUBEIXIAZHU:     2.XUNHUANXITONG:OUYOUXINJI、MAIPIN、FARE、TOUYUN、XUEYADI。

     3.XIAOHUAXITONG:OUYOUWEIBUBUSHI、SHANGFUBUTONG、FUBUZHANGMANGAN、SHIYUBUZHEN、EXIN、OUTU、RUANBIAN、FUXIE。

OUZHOUBEIXIAZHU:     4.GUOMINFANYING:OUYOUPIZHEN、FAZHEN、QIANMAZHEN、SAOYANGGAN。

     5.SHENJINGXITONG:OUYOUTOUTONG、TOUZHONGGAN、YANHUA、XUANYUN、SHIMIAN、FAMA、OUGANKUNJUAN、FALI。

OUZHOUBEIXIAZHU:     6.GANZANG:OUYOUAST、ALT、LDHZHISHANGSHENG。

OUZHOUBEIXIAZHU:     7.SHENZANG:OUYOUBUN、JISUAN、NIAOSUANZHISHANGSHENG。

OUZHOUBEIXIAZHU:     8.QITA:OUYOUFUZHONG、TENGTONG。

     9.CHUXUEQINGXIANG:OUYOUXIAOHUADAOCHUXUE、BICHUXUE、PIXIACHUXUE、YANDICHUXUE、XUENIAODENGCHUXUEQINGXIANG。

欧洲杯下注:

OUZHOUBEIXIAZHU:【JIN    JI】YIXIAHUANZHEJINFU:

OUZHOUBEIXIAZHU:     1.DUIBENYAORENHECHENGFENGUOMINZHE。

OUZHOUBEIXIAZHU:     2.HUANYOU3-4JICHONGXUEXINGXINLISHUAIJIEDEBINGREN。

     3.CHUXUEHUANZHERUXUEYOUBING、MAOXIXUEGUANCUIRUOZHENG、SHANGXIAOHUADAOCHUXUE、KEXUEDENG。

OUZHOUBEIXIAZHU:     4.RENSHENHUOYOUKENENGRENSHENDEFUNV。

欧洲杯下注:

OUZHOUBEIXIAZHU:【ZHUYISHIXIANG】

OUZHOUBEIXIAZHU:     1.RUGUOCHUXIANPIZHEN、FAZHEN、QIANMAZHEN、SAOYANGGAN,YINGTINGYAO。

     2.RUGUOCHUXIANXINTIAOJIAKUAI、FARE、TOUTONG、TOUZHONGGAN、TOUYUN、YANHUA、FAMA、OUGANKUNJUAN、SHIMIAN、DIXUEYA,YINGJIANLIANGHUOTINGYAO。

     3.YIXIAHUANZHESHENFUBENPIN:YUEJINGQIDEHUANZHE、YOUCHUXUEQINGXIANGDEHUANZHE;ZHENGZAISHIYONGKANGNINGYAOHUOKANGXUEXIAOBANYAO(RUASIPILIN、SAILVPIDINGDENG)DEHUANZHE;ZHONGZHENGGAN、SHENGONGNENGZHANGAIHUANZHE。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YUNFUJIBURUQIFUNVYONGYAO】 RENSHENJIBURUQIFUNVHUOJIHUA/KENENGRENSHENDEFUNVJINYONG。

欧洲杯下注:

OUZHOUBEIXIAZHU:【ERTONGYONGYAO】YOUGUANERTONGFUYONGDEANQUANXINGSHANGWEIQUEDING。

欧洲杯下注:

OUZHOUBEIXIAZHU:【LAONIANYONGYAO】WEIJINXINGGAIXIANGSHIYANQIEWUKEKAOCANKAOWENXIAN。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAOWUXIANGHUZUOYONG】QIANLIEXIANSUE1YUBENPINQIXIETONGZUOYONG,ZENGJIAXIBAONEIHUANXIANGAN—LINSUANJIZENGQIANGLIAOXIAO。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAOWUGUOLIANG】

     WEIJIANBENPINJIXINGGUOLIANGBAODAO。JIXINGGUOLIANGKEYITONGGUOQICHUXIANZHENGZHUANGLAIYUCE,RUCHUXIANJULIETOUTONG、FUXIE、DIXUEYA、XINDONGGUOSU,XINLVBUQIDENG。YIDANCHUXIANSHANGSHUZHENGZHUANG,YINGDUIBINGRENJINXINGYANMIGUANCHA,BINGDUIZHENGCHULI。YOUYUBENYAODEDANBAIJIEHELVGAO,XUEYETOUXIBUNENGYOUXIAOJIANGQIQINGCHU。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAOLIDULI】

OUZHOUBEIXIAZHU:      YAOLIZUOYONG

      本品改善间歇性跛行症状的作用机制尚不完全清楚。本品及其代谢产物是环腺苷酸(cAMP)磷酸二酯酶 lll 抑制剂(PDE lll 抑制剂),可以通过抑制磷酸二酯酶活性而减少cAMP的降解,从而升高血小板和血管内cAMP水平,发挥抑制血小板聚集和舒张血管的作用。

      BENPINNENGGOUKENIXINGDEYIZHININGXUEMEI、ADP、JIAOYUAN、HUASHENGSIXISUAN、SHENSHANGXIANSUDENGYINQIDEXUEXIAOBANJUJI。GUOWAILINCHUANGYANJIUXIANSHI,BINGRENKOUFUBENPIN100mg/CI,YITIANLIANGCI,LIANXU12ZHOUHOU,GANYOUSANZHISHUIPINGXIAJIANGYUE15%,GAOMIDUZHIDANBAISHUIPINGSHENGGAOYUE10%。

OUZHOUBEIXIAZHU:    DULIYANJIU

    ZHONGFUJIYAODUXING:QUANZHONGFUJINGKOUJIYUBENPINKEDAOZHIXINXUEGUANSUNSHANG,BAOKUOZUOXINSHIXINNEIMOCHUXUE、HANTIEXUEHUANGSUCHENJIJIXIANWEIHUA,YOUXINFANGBICHUXUE,GUANZHUANGDONGMAIBIPINGHUAJICHUXUE、HUAISI,GUANZHUANGDONGMAINEIMOZENGHOU,GUANZHUANGDONGMAIYANHEWAIZHOUDONGMAIYAN。ZAI52ZHOUDESHIYANYANJIUZHONG,ZUIDIJILIANGCHANSHENGXINXUEGUANSUNSHANGSHIYOULIYAOWUDEQUANSHENBAOLULIANG(AUC)BIRENFUYONGZUIDATUIJIANJILIANG(MRHD,WEI100mg,MEIRILIANGCI)SHIDEDI。QUANLEISISUNSHANGDEBAODAOYIJIANYUYINGYONGQITAZHENGXINGJILIYAO(BAOKUOPDEⅢYIZHIJI)HE/HUOXUEGUANKUOZHANGJI。CI、XIONGDASHULIANXUJIYUBENPIN5HUO13ZHOU,DANGAUCFENBIESHIRENFUYONGMRHDSHIAUCDE1.5HE5BEISHIWEIGUANCHADAOXINXUEGUANSUNSHANG。HOUJINGKOUYINGYONGBENPIN1800mg/kg/RI,LIANXU13ZHOUYIWEIJIANXINXUEGUANSUNSHANG,ERCIFAHUIYAOLIZUOYONGJILIANGSHIDEAUCDIYURENFUYONGMRHDJIGOUCHANSHENGXINXUEGUANSUNSHANGJILIANGSHISUODAAUC。

    YICHUANDUXING:BENPINXIJUNTUBIANSHIYAN、DNAXIUFUSHIYAN、BURUXIBAOJIYINTUBIANJIZAITIXIAOSHUGUSUIRANSETIJIBIANSHIYANJIEGUOJUNWEIYINXING。DANTIWAIZHONGGUOCANGSHULUANCHAOXIBAOSHIYANZHONG,BENPINKEXIANZHUZENGJIARANSETIJIBIANLV。

    SHENGZHIDUXING:CIXINGDASHUJINGKOUJIYUBENPIN1000mg/kg/RIKEJIANGDIQITAIZITIZHONG,ZENGJIATAIZIXINXUEGUAN、SHENJIGUGEYICHANGDEFASHENGLV,BIAOXIANWEISHIJIANGE、ZHUDONGMAIGONG、SUOGUXIADONGMAIFAYUZHENGCHANG,SHENYUKUOZHANG,CHUXIAN14LEI,GUHUAYANCHI;FEIYUNCIXINGDASHUYINGYONGSHANGSHUJILIANGSHIYOULIYAOWUDEAUCSHIRENFUYONGMRHDSHIAUCDE5BEI。CIXINGDASHUJIYAO150mg/kg/RI(AUCSHIRENFUYONGMRHDSHIAUCDE5BEI,YU1500mg/kg/RISHIDEAUCXIANGTONG)KESHISHIJIANGEQUESUNHEGUHUAYANCHIDEFASHENGLVZENGJIA。TUSHENGZHIDUXINGYANJIUFAXIAN,BENPINZAIDIZHI150mg/kg/RISHIJIKESHIXIONGGUGUHUAYANCHIDEFASHENGLVZENGJIA,FEIYUNTUJIYUBENPIN150mg/kg/RISHIYOULIYAOWUAUCYUANDIYURENFUYONGMRHDSHIDEAUC。

    WEICHANQIDASHUJIYAO150mg/kg/RI,SITAIFASHENGLVZENGJIA,TAIZITIZHONGJIANGDI。SHANGWUHUAIYUNFUNVFUYONGBENPINDECHONGFENHEYANGEDUIZHAODELINCHUANGYANJIUZILIAO。

    ZHIAIXING:CI、XIONGDASHU(DA500mg/kg/RI)JIXIAOSHU(DA1000mg/kg/RI)LIANXUCHANSHIFAJIYUBENPIN104ZHOU,WEIJIANZHIAIZUOYONG,DANDONGWUZAIZUIGAOJILIANGSHIDADAODEQUANSHENBAOLULIANGBIRENFUYONGMRHDSHIDEDI。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YAODAIDONGLIXUE】

OUZHOUBEIXIAZHU:    JUPDR57BAN:

    本品口服后绝对生物利用度尚不明确。脂餐后吸收增加,Cmax增加约90%,AUC增加约25%。本药主要通过肝脏细胞色素酶P-450代谢(主要为3A4,),代谢物主要经尿排泄。两种代谢产物具有明确的药理活性,一为3,4-二氢-西洛他唑(3,4-dehydro-cilostazol),活性为原药的4~7倍,约占本药口服后总药理活性的50%;一为4 -顺式-羟基-西洛他唑(4 -trans-hydroxy-cilostazol),活性为原药的1/5。本品及其具有药理活性的代谢物的药代动力学特征呈剂量相关性。本药及具药理活性的代谢物的半衰期约为11~13小时,长期给药后本药及其代谢产物可引起体内蓄积,数天内血药浓度达稳态。本药及两个具有药理活性的代谢产物的药代动力学特征在健康志愿者与慢性动脉硬化性闭塞症引起的间歇跛行患者间没有显著差异。

OUZHOUBEIXIAZHU:    

    BENYAODEXUEJIANGDANBAI(ZHUYAOSHIBAIDANBAI)JIEHELVWEI95%-98%,3,4-ERQING-XILUOTAZUOWEI97.4%,4 -SHUNSHI-QIANGJI-XILUOTAZUOWEI66%。QINGDUDEGANSUNHAIBUYINGXIANGDANBAIJIEHE。SHENGONGNENGBUQUANHUANZHEXUEJIANGZHONGYOULIDEXILUOTAZUOBIJIANKANGZHEGAO27%。HONGMEISU、KUINIDING、HUAFALING、AOMEILAZUODUIXUEJIANGZHONGDEXILUOTAZUODEXUEJIANGZHIHUANDEYINGXIANGMEIYOUDAOJUYOULINCHUANGYIYIDECHENGDU。

欧洲杯下注:

    BENYAOZHUYAOYIDAIXIECHANWUDEXINGSHIXIAOCHU,ERDAIXIECHANWUZEZHUYAOCONGNIAOZHONGPAIXIE。XILUOTAZUODAIXIEDEZHUYAOTONGGONGMEIWEICYP3A4,SHAOBUFENWEICYP2C19。KOUFUFANGSHEXINGBIAOZHIDEXILUOTAZUO100mg,XUEJIANGFENXIWUZHONG56%WEIXILUOTAZUO,15%WEI3,4-ERQING-XILUOTAZUO,4%WEI4 -SHUNSHI-QIANGJI-XILUOTAZUO。74%CONGNIAOZHONGPAIXIE,20%CONGFENZHONGPAIXIE。YUANYAOZAINIAOZHONGSHUCEBUCHUSHUIPING,BUZU2%DEJIYAOJILIANGYI3,4-ERQING-XILUOTAZUOXINGSHICONGNIAOZHONGPAIXIE。30%YI4 -SHUNSHI-QIANGJI-XILUOTAZUOXINGSHICONGNIAOZHONGPAIXIE,BUZU5%DEJIYAOJILIANGYIQITADAIXIECHANWUXINGSHIPAIXIE。

欧洲杯下注:

OUZHOUBEIXIAZHU:【ZHU    ZANG】MIFENGBAOCUN。

欧洲杯下注:

【BAO    ZHUANG】LVSUBAOZHUANG;6PIAN/BAN、8PIAN/BAN、10PIAN/BAN、12PIAN/BAN;1BAN/HE、2BAN/HE。

欧洲杯下注:

OUZHOUBEIXIAZHU:【YOU XIAO QI】24GEYUE

欧洲杯下注:

OUZHOUBEIXIAZHU:【ZHIXINGBIAOZHUN】WS1-(X-001)-2001Z

欧洲杯下注:

OUZHOUBEIXIAZHU:【PIZHUNWENHAO】《ZHONGGUOYAODIAN》2015NIANBANDIYIZENGBUBEN

欧洲杯下注:

OUZHOUBEIXIAZHU:【SHENGCHANQIYE】

OUZHOUBEIXIAZHU:    QIYEMINGCHENG:SHANDONGLUOXINYAOYEJITUANGUFENYOUXIANGONGSI

OUZHOUBEIXIAZHU:    SHENGCHANDIZHI:SHANDONGSHENGLINYIGAOXINJISHUCHANYEKAIFAQULUOQILU

OUZHOUBEIXIAZHU:    YOUZHENGBIANMA:276017

OUZHOUBEIXIAZHU:    DIANHUAHAOMA:0539-8257899、8481991

OUZHOUBEIXIAZHU:    CHUANZHENHAOMA:0539-8481990

OUZHOUBEIXIAZHU:    SHOUHOUFUWU:0539-8242699

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GAISHANMANXINGDONGMAIYINGHUAXINGBISAIZHENGYINQIDEMANXINGKUIYANG、TENGTONG、FALENGJIJIANXIEBOXINGDENGZHENGZHUANG。

KOUFU,YICI 100mg(ERPIAN),1RI2CI。KEGENJUBINGQINGSHIDANGZENGJIAN。

 


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